DNA complexes with phosphatidylcholine-detergent conjugates are administered in mouse airways, and transgene expression and inflammatory activity as an index of toxicity are investigated as a function of time, DNA dose, and presence of helper and stealth lipids.
Lentiviral particles of GADD34 RNAi were purchased from Santa Cruz (Santa Cruz, CA, USA) and administered in mouse brain according to the protocol described previously.
The t R of the intact analogs was established after co-injection with radiolabeled samples not administered in mice (Figure 5 C,D, respectively).
Our results show that there was no correlation between survival, at the ileum level, of bacteria intragastrically administered in mice and bacteria sensitivity or resistance to lysozyme.
The behavioral actions of these sulfamides, i.p. administered in mice, were examined in the plus-maze, hole-board and locomotor activity assays.
With the daily exposure to stressor for 5 consecutive weeks, TPs were administered in mice at a daily dose of 25 mg/kg or 50 mg/kg by gavage for 3 consecutive weeks from the 3rd week.
Peptide antigens of malaria carried with PLGA microparticles induced stronger systemic immune response compared to those absorbed to alum either orally or subcutaneously administered in mice, and meanwhile the Th1-mediated cellular immune response was only observed in the previous formulation (Carcaboso et al., 2003).
In the second experiment we observed that the dose of 70 mg/kg of thioridazine, daily administered in mice infected with an MDR-TB strain significantly reduced the CFUs at 30 and 60 days (5.1×105, SD 6×104) after initiation of treatment (p<0.009), whereas CFUs rose progressively in the untreated control animals (2.75×106, SD 5×104. Figure 2).
The ether analogue 4 was unable to stimulate any cytokine response when administered in mice.
In a related study, the same protein administered in mice had antihelminthic activity against Heligmosomoides bakeri [ 9].
LY294002 causes severe dermal toxicity [ 27], and wortmannin and its analog has shown hepatic toxicity [ 28] when administered in mice.
