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Patches were administered in weekly intervals during December 2008 to February 2009, that is before the pollen season 2009.
A Japanese group has recently published a phase I study, implementing a single VEGFR-2-derived peptide administered in weekly intervals via the subcutaneous route of administration, thus following a similar approach, but restricting it to a certain HLA type [ 29].
To evaluate the safety and efficacy of epoetin alfa administered in extended-dosing intervals to a target hemoglobin (Hb) level not exceeding 12.0 g/dL for the treatment of anemia in subjects with chronic kidney disease (CKD) not on dialysis.
Recommended treatment consists of intramuscular injections of 155 U divided among 7 head/neck muscles administered in ~12-week intervals [22].
Stimuli were administered in duplicates at intervals of approximately 30 s.
In all groups, drugs were administered in 2-week intervals.
With intensive administrative and electronic support, this battery of questionnaires was administered in three month intervals.
In responders repeat cycles are administered in 12 week intervals up to a total of 3 cycles.
However, the incidence of marked skin toxicity observed in our study, is significantly lower than that usually reported when lower doses of PLD (35 mg m−2) are administered in shorter time intervals, every 3 weeks (Gogas et al, 2002).
The aim of the study was to evaluate whether three intravenous infusions of 4 mg zoledronic acid (Zometa, administered in 1-month intervals) would accelerate clinical resolution of acute Charcot neuroarthropathy in the midfoot.
PET/CT and intratumoral oxygen probe measurements were performed one week apart with treatment administered in the intervening interval.
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