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To test whether these modifications in dopamine efflux were responsible for the observed neuroeconomic deficits, PPX was administered in combination with the monoamine-depleting agent reserpine (RES), at a low dose (1 mg/kg/day, SC) that did not affect baseline locomotor and operant responses.
To assess the safety and efficacy of E10030 (Fovista; Ophthotech, New York, NY), a platelet-derived growth factor (PDGF) antagonist, administered in combination with the anti vascular endothelial growth factor (VEGF) agent ranibizumab (Lucentis; Roche, Basel, Switzerland) compared with ranibizumab monotherapy in patients with neovascular age-related macular degeneration (nAMD).
The same dose of CsA is, however, much more effective when administered in combination with the allochimeric molecule [5] [8].
However, recent results demonstrated its in vivo activity in Ph-ALL xenograft models, when administered in combination with the mammalian target of rapamycin (mTOR) inhibitor rapamycin [25].
Its uptake into the brain could be enhanced when drugs are administered in combination with the P-gp efflux inhibitor, rifampicin [ 48, 134].
Interestingly, in therapeutic treatment, these mAbs showed a synergistic effect when administered in combination, with the total amount of mAbs injected being the same of the single-mAbs.
Similar(43)
For those patients who progressed on irinotecan-based regimens, cetuximab was administered in combination with these regimens given at the same dose and schedule.
The antibody-based pharmacodelivery of TNF by the fusion protein 'F8 TNF' to oncofetal fibronectin in sarcoma-bearing mice leads to complete and long-lasting tumour eradications when administered in combination with doxorubicin, the first-line drug for the treatment of sarcomas in humans.
Despite the much lower dose of TMZ administered in combination with LM, the levels of O-meG were significantly greater in the PBMC of patients on combination therapy.
When administered in combination with pioglitazone, the GMR (90% CI) for the Cmax of luseogliflozin was 1.16 (1.30, 1.30).
In two of these studies, Vorinostat was administered in combination with either the proteasome inhibitor Bortezomib alone or the combination of Bortezomib and pegylated liposomal Doxorubicine (Badros et al. 2009; Voorhees et al. 2009).
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