The phrase "administered in basal" is not correct and does not convey a clear meaning in written English.
It may be intended to refer to administering something in a basal or foundational manner, but the phrasing is awkward and unclear.
Example: "The medication was administered in basal conditions to ensure accurate results."
Alternatives: "administered at baseline" or "given in a basal state".
BEGIN Once Long is the largest phase 3 study in the clinical development program of insulin degludec and was designed as a 52-week, treat-to-target trial to compare the efficacy and safety of insulin degludec with those of insulin glargine, both administered in a basal regimen in combination with metformin, in insulin-naive participants with type 2 diabetes inadequately controlled with OADs.
Using one injection of a long-acting or intermediate-acting insulin can provide adequate coverage in some patients as long as the dosage is appropriately individualized; however, most patients will require rapid- or short-acting insulin administered in combination with the basal insulin at meals, particularly at the evening meal, which typically contains a larger caloric load.
Basal insulin was administered in the thigh and aspart in the abdomen.
Moreover, in this study, basal insulin was administered in the morning to evaluate potential FBG differences as a result of a considerable difference in the half-lives of the two basal insulins, but FBG measures were similar.
25, 77 It is important to realize that the duration of action of subcutaneously injected insulin is dose-proportionate, 34, 103 and that relatively high doses of basal insulin are administered in type 2 diabetes due to the tendency for patients to be heavy and insulin-resistant.
Evidence of better treatment adherence by individuals needing more basal insulin than can be administered in a single injection of U100 insulin would be of interest, but this is still lacking.
Furthermore, twice as many patients in the basal insulin cohort achieved target A1C <7% in the APOLLO trial compared with the 4-T study, despite apparently equivalent insulin doses administered in both studies, and despite the twice-daily dose of basal insulin detemir that was required in 34% of the patients in the 4-T study (Table 3).
Prandial insulin was preferentially titrated first unless the subject was NPO or the total dose of prandial insulin administered in the previous 24-h period exceeded twice that of the basal insulin.
When the components were administered in combination at the highest concentrations used, they markedly and significantly reduced ROS production in NCTC 2544 cells, both in basal conditions (93% reduction, P < 0.027), as well as with H2O2 (57% reduction, P < 0.0099).
Close-ended questionnaire (N = 247) on the phenomena was administered in each building.
