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Rat intestinal I/R model was established with clamping the superior mesenteric artery (SMA) and 6G was intragastrically administered for three consecutive days before I/R injury.
It was developed and approved in 2003 for the prevention of chemotherapy-induced emesis and is usually administered for three days only [23], [24].
That the two classes of compounds have a synergetic action when chronically administered for three days was confirmed by assessing their combined influence on CREB activation.
These observations, combined with the fact that pyronaridine-artesunate is only administered for three days suggest that there is a very low risk of liver injury with pyronaridine-artesunate. Mixed P. vivax and P. falciparum infection and P. falciparum reinfection are common in areas endemic for P. vivax.
Intravenous pulse methylprednisolone (30 mg/kg/day) was administered for three days, and prednisone (2 mg/kg every day on a weaning regimen) was continued.
Based on these results, a training program was designed and administered for three months to six of the athletes (the others acting as control group).
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or saline treatment was administered for five weeks starting from the third week of CMS.
Diosgenin (100 mg/kg b.w./day) was orally administered for four weeks, while C group received the vehicle alone.
The free drug was administered for eight consecutive days at 50 mg/kg by intraperitoneal route (i.p).
To avoid heterotopic ossification of the soft tissues at the elbow, indomethacin 25 mg bid was administered for four weeks postoperatively.
A two-step revision procedure was performed and antibiotic therapy was administered for four months between implant removal and revision (600 mg teicoplanin twice daily and 1 g ceftriaxone twice daily).
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