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Intra-tumor distribution of sequentially administered "empty" PEGylated liposomes was altered in a dosing interval-dependent manner.
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The new possession proved difficult to administer as empty coffers and insensitivity to Afrikaner resentments led to a clash over tax payments, and, under a triumvirate of Paul Kruger, Piet Joubert, and Marthinus Wessel Pretorius, the Transvaal Boers opted to fight for independence.
Primaquine may also cause abdominal pain if administered on an empty stomach.
Patients received nilotinib 400 mg twice daily, administered on an empty stomach.
The recommended dose is 20 mg twice daily at least 1 hour before meals or administered on an empty stomach.
Each drink was administered on an empty stomach (i.e. no food after 22.00 hours and no drink after 24.00 hours the evening before) over consecutive days, after which the mean daily iron absorption was calculated.
Patients received selumetinib hydrogen sulphate capsules orally twice daily continuously on a 28-day cycle, administered on an empty stomach based on prior favourable PK data with fasting (Leijen et al, 2011).
SB939 was administered in an empty stomach as there were no data available on the effect of food intake on drug absorption at the time the trial was initiated.
In rare instances in which didanosine is used as part of a treatment regimen, it should be administered on an empty stomach at least 2 hours before or at least 4 hours after rilpivirine administration, and the simultaneous use of two non-NRTIs is never appropriate.
E7080 was administered orally on an empty stomach (after an overnight fast) on a continuous once-daily administration schedule, with one cycle of treatment consisting of 28 days.
This was a two-centre, single-agent, open-label dose-escalation phase I study in which SB939 was administered orally in an empty stomach (⩾1 h before a meal or 2 h after).
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