Exact(1)
For RCTs in which different doses of biologic DMARDs were administered, efficacy estimates based on all study arms were included.
Similar(59)
Golimumab doses were administered after efficacy assessments.
Such an effect has previously been noted in a murine model, in which a pair of T-cell- and antibody-inducing vaccines, each with around 30 35% sterile efficacy when administered alone, elicited 90% sterile efficacy upon their combination.
A billion MSCs need to be administered for therapeutic efficacy, however, because only ∼1% of the cells reach the ischemic myocardium after systemic infusion.
The analysis paid particular attention to the relationship between age, the drug dose administered, and treatment efficacy.
We extracted detailed information on trial design, inclusion/exclusion criteria, participant characteristics, vaccine and placebo administered, trial endpoints, efficacy populations, and methodological quality from all included trials.
Unfortunately, BH4 is very unstable and, when orally administered, has limited efficacy likely due to oxidation during absorption (Cunnington et al., 2012).
Meloxicam was selected as the positive control since it is registered and extensively used in dogs, and its efficacy administered by injection prior to surgery in dogs undergoing soft tissue surgery has been proven via superiority to butorphanol or placebo [ 9- 11].
This is supported by Mavis, who administered a self-efficacy survey to students ten minutes before their OSCE examination, and found that their subsequent attainment was "the product of complex relationships between skills and knowledge, mediated by students perceptions of anxiety, self-confidence and preparedness" [ 3].
The combination physostigmine (0.3 mg/kg) and obidoxime (3.1 mg/kg), showing outstanding efficacy when administered at 1 min after poisoning, showed full efficacy in two out of six animals, but in four out of six animals, lethality was accelerated when the combination was administered at 10 min.
The finding that aspirin exerted chemopreventive efficacy when administered in utero and during weaning is consistent with these pharmacokinetic considerations, in that efficacy was probably the consequence of efficacious levels of salicylate in the mother's milk and the embryonic blood and tissues.
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