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Arterial washin of desflurane was initially rapid; arterial concentrations reached 50% of administered concentrations within 4 minutes, but then slowed, reaching 68% of inspired concentrations at 32 minutes (desflurane concentration 4.0% ± 0.3%).
However, unlike the DOX-MWCNTs-PEG which did not result in appreciable cytotoxicity at the administered concentrations, DOX-MWCNTs-PEG-TAT exhibited much higher cytotoxicity and was even comparable to free DOX especially at relatively high doses, indicating that the antiproliferative effect of the drug-loaded MWCNTs was significantly increased by the modification of TAT.
Gerbils exhibited toxic reactions to the different administered concentrations in this study.
The values of AST, uric acid, and bilirubin were not related to the administered concentrations of PPE, so these alterations may not be due to the plaunotol extract.
For example, clinicians in the study by Wells and colleagues used both boluses and infusions of HTS with a range of administered concentrations (3% versus 7.5%).
Because this shift in gene expression cannot be fully accounted for by deviations in the administered concentrations from the nominal concentrations, we verified the apparent clustering by assigning predicted concentration levels to all the samples with a support vector machine (SVM).
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Furthermore, at the highest administered concentration, 150 μg/L, FN completely inhibited spiggin production.
The administered concentration of the nanoparticles was adjusted to the free flurbiprofen, which corresponds to approximately 65 μg/cm to 317 μg/cm nanoparticles.
At its lowest administered concentration, only 15 μg/L, its antiandrogenic activity was analogous to the activity of the pharmaceutical antiandrogen FL at 250 μg/L.
A potential beneficial effect of exogenous CO may highly depend on the pathological condition, the mode, time point and duration of application, the administered concentration, and on the target tissue.
The protective effects of exogenous CO may strongly depend on the pathological condition, the mode, time point and duration of application, the administered concentration, and on the target tissue and cell.
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