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In the PBPK model simulations, sirolimus was administrated as an oral dose of 1.0 mg/m twice a day for 30 days, in accordance with the actually administered average dose of 1.0 mg/m between start and 1 month of therapy (0.8 ± 0.1 and 1.3 ± 0.4 mg/m, respectively).
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The values of UFH administered averaged 778 ± 601 IU/h IVSE.
The second assessment was administered, on average, 30 months after a woman's diagnosis (30-month assessment).
This vaccination had been administered, on average, 4.5 years (ranging from one to seven years) before our test.
To be considered as accelerated radiation more than 10 Gy total dose per week had to be administered on average during the radiation series.
The majority of patients underwent either computer tomography (45%) or cardiac catheterization with or without PCI (21 and 24%, respectively), and 100 (IQR 80 160) mL of CM was administered on average during contrast procedures.
The last assessment was administered, on average, 123 months after a woman's diagnosis (123-month assessment) by telephone interview in New Mexico and Los Angeles County and by mailed questionnaire or telephone interview in Western Washington.
When time was examined as a continuous variable, deliveries in which oxytocin was prepared and available at bedside had oxytocin administered, on average, about 3 minutes sooner than deliveries in which oxytocin was not ready for administration at bedside, after adjusting for time of delivery and maternal hemorrhage risk factors (–2.9 minutes, 95% CI = –5.0, –0.9).
While the relative sedating effects of haloperidol versus quetiapine are not well quantified, if haloperidol has the greater sedative effect, the fact that nearly twice as much "as needed" haloperidol was administered on average to the placebo group may also account for the faster resolution of agitation in this group.
The third assessment was administered, on average, 40 months after a woman's diagnosis (40-month assessment) by telephone interview or mailed questionnaire in New Mexico, by mailed questionnaire plus telephone follow-up in Western Washington, and by telephone interview in Los Angeles County.
The effects of each intervention are summarized in Table 2. Inotropic stimulation (DOBU) was achieved by administering an average 23 μg/kg/minute dose of dobutamine, hypovolemia (HYPO) by an average 1.2 l controlled hemorrhage, and hypervolemia (HYPER) by the average infusion of 4.5 l serum saline and 1.5 l gelatin.
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