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The anti-angiogenic effects of UFT are amplified when administered at lower, non toxic daily doses [ 19].
Thus, these potent analgesic and antiinflammatory effects observed with PEA-LUT were in contrast to those observed with the individual substances administered at lower doses (data not shown).
The insulin regimen was more intensive in the patients fed by the post-pyloric route with insulin administered at lower blood glucose concentrations.
Metronomic chemotherapy (i.e. chemotherapy administered at lower doses at more frequent intervals) has also shown antiangiogenic properties through increased endothelial cell apoptosis [ 11- 17].
In this study, we sought to determine whether gemcitabine administered at lower doses in a metronomic regimen has anti-tumour activity in pancreatic ductal adenocarcinoma.
It also causes delayed persisting effects in pups when administered at lower doses during pregnancy, enhancing susceptibility to agents that induce seizures and memory loss (Dakshinamurti et al. 1993; Levin et al. 2005).
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In selected cases where there is no alternative treatment, anti-VEGF agents can be re-administered at lower dose with close monitoring of blood pressure [ 17].
However, the wide-spread presence of resistant strains results in a higher overall attack rate than would have been the case if treatment were administered at a lower rate.
In this context, it should be administered at much lower doses than in MM to avoid the dangerous flair phenomenon.
Of note, when flaxseed was administered at a lower dose, it delayed the onset of puberty (Tou et al. 1998).
The effects of photosensitiser alone on SLs are expected to be less pronounced, with more potent sensitising agents administered at much lower doses than Photofrin.
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