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Risk factors were defined from questionnaires administered at initial assessment (wave 1) and the time of blood sampling (wave 2).
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Sertraline will be administered at an initial dose of 50 mg once daily or matching placebo followed by a dose escalation strategy consisting of 50 mg increments at 2 week intervals (as tolerated) to a maximum dose of 200 mg.
It consisted of vinorelbine at 15 mg/m2 and carboplatin administered at an initial area under the curve (AUC) of 1.5, and increased by an AUC of 0.5 per dose level to a maximum AUC of 3, corresponding with an AUC of 6 per cycle of chemotherapy.
Trabectedin was administered at an initial dose of 1.5 mg/m, q3 weeks.
The CGI was administered at the initial and final study visit.
Midazolam should be administered at an initial dose of 0.1 mg/kg, preceded by 0.05 mg/kg as a bolus.
An induction course of temozolomide was administered at an initial dose of 75 mg/m daily alongside radiotherapy (42 d).
Cetuximab was administered at an initial dose of 400 mg/m, then 250 mg/m once a week thereafter.
At 52 weeks, all participants were asked to come in for a follow-up appointment and complete the same questionnaire administered at the initial baseline visit.
The Wechsler Intelligence Scale for Children-IV (WISC-IV) was administered at the initial study visit at the time of biological sample collection.
26 In a dose-escalation trial, epoetin alfa was administered at an initial dose of 150 U/kg three times per week.
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