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Anti-inflammatory drugs are only effective when administered at high doses that may cause side effects.
The results of cytotoxicity assay show that MSNs are not toxic, even when administered at high concentrations (50 μg/mL).
Local and systemic treatment with steroids has not been proven effective in the treatment of CNV associated with PIC, even when administered at high doses for many months [6, 10].
While naloxone can cause confusion and "fight or flight" response when administered at high doses, in smaller amounts, naloxone rarely causes overdose victims to become combative.
However, when CpdA was administered at high concentration it turned out to be lethal.
When administered at high doses, S. Typhimurium rpoS mutants can protect against homologous, but not heterologous challenge [26], [27].
Similar(7)
Similarly, whether tirofiban administered at high-bolus dose (HBD) followed by standard infusion is a valuable alternative to abciximab in the setting of ST-segment elevation myocardial infarction remains uncertain.
A reduced concentration of gammaglobulins has been reported in the sera of a fraction of patients (one fourth) receiving imatinib treatment [33]; however, in that case, imatinib was administered at higher doses (up to 600 mg/daily) than in our study and only peripheral blood serum was considered.
The rodent bioassay data indicate that methyl eugenol, along with some structural analogs and when administered at high-bolus doses, may cause a shift in metabolism, resulting in the formation of a reactive carbonium ion intermediate.
Therefore, dextro-naltrexone might be administered at higher dosages, yielding greater microglia-suppressing activities while minimizing side effects.
1 The authors suggested that oxytocin should be administered at higher concentrations, and fluid balance supervised closely during labour.
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