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Many drugs with the sulfonamide group are safe and efficacious when administered at a relatively low dose and for a short duration.
CS is administered at a relatively low molecular weight (14 17 kDa), important for gastrointestinal absorption [ 44, 46], and is further depolymerized but not completely degraded [ 44, 47, 48].
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However, in one study curcumin was administered at a much lower dose (3 mg/kg) and this yielded relatively high brain levels of approximately 3.2 nmol/g at four hours after intramuscular injection [ 15].
CMS was administered at a dose of 3 m.
Formulations A and B were administered to rats at a 20 mg/kg dose, while Formulations C and D were administered at a 40 mg/kg dose.
Most insurance does cover vaccinations administered at a doctor's office.
A drug is to be administered at a dosage rate of 1 mg/kg.
Additionally, other data indicate that antisense DNA exhibits efficacy in vivo when administered at the relatively high concentration of 5 mM (Whitesell et al. [1991]).
In order to demonstrate the functionality and extended pharmacokinetic profile of the molecule, a dose of Gcg-XTEN was administered at relatively high dose (12 nmol/kg) where an increase in blood glucose levels was expected.
Our findings may have been influenced by several factors: chemotherapy administered at relatively low doses while following a frequent metronomic schedule may have optimised the antiangiogenic effect of cytotoxic agents, providing better results than an intensified weekly schedule (Kurzen et al, 2003).
For example, antibodies and other binding scaffolds usually need to be administered at relatively high concentrations in order to generate a suitable response in patients.
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