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In order to determine if physiologically relevant concentrations of LDL or HDL mediated the uptake of cholesteryl esters, LDL or HDL were administered as indicated above.
For some experiments, an anti-PSGL-1 antibody (4RA10, rat IgG1, BioXCell, West Lebanon, NH, USA), or purified rat IgG (Sigma) were administered, as indicated.
Adjuvant axillary irradiation, systemic chemotherapy, and antiestrogen therapy were then offered and administered as indicated per current post-surgical standard of care.
Treatments were administered as indicated using vehicle (PBS containing 0.1% BSA), doxorubicin (2 8 mg/kg), Apo2L/TRAIL (500 μg/animal), or a combination of 4 mg/kg doxorubicin followed by 500 μg Apo2L/TRAIL.
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Where anxiety, psychotic, or eating disorder was indicated based on SCID screening, these modules were administered as well.
In those cases where self-reports indicated severe pain, rescue analgesia or stepped up analgesia was administered as soon as possible while the second assessment was done.
HPV vaccines can be administered as early as nine.
Anti-epileptics were administered as medically indicated.
Full supportive care, including antibiotics, antiemetics, and granulocyte colony-stimulation factors, was administered as clinically indicated.
Intravenous sedation was administered as clinically indicated, and subsequent care of the patient may have included general anesthesia.
Subsequently, open label infusions of sedative/analgesic agents were administered as clinically indicated and according to standard therapy following discontinuation of study opioid infusions.
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