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The fasted volunteers administered a dosing capsule with water likely limited bioavailability.
Traditionally, this has been achieved by simulating, for example, concentration time profiles for several individuals administered a dosing regimen (i.e., using NONMEM®), 13 plotting the outcome (often summarized by a median and confidence intervals) and saving the image, and repeating the process for a new dose.
Similar(58)
They are pursuing a homicide case against his personal physician, who reportedly administered a dose of a powerful anesthetic, propofol, before he died.
Fuentes administered a dose of medicine and later advised the parents to take the child to another hospital.
In 1885, the French biologist Louis Pasteur administered a dose of an experimental vaccine to a 9-year old boy who'd been mauled by a rabid dog.
The physician administered a dose of intravenous morphine, and as the drug took effect, the woman's body eased and she began to weep.
Patients suffering from a condition known as angina pectoris were administered a dose of amyl nitrite in order to dilate their arteries, stimulate blood flow to the heart muscle, and alleviate pain and discomfort.
We administered a dose of 25Gy to adult rat brains while shielding the olfactory bulbs.
In the remaining 23.4%, the doctor or pharmacist administered a dose that differed from the computer recommendation.
Patients were administered a dose of 800 mg of pazopanib once daily that was reduced in case of intolerance.
And a conscience isn't much good if all it does is make you sputter for a few moments on your way to administering a dose of poison.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com