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In this case, we initially planned to administer radiation therapy to the nerve plexus around the SMA combined with S-1 therapy, expecting a highly favorable response of the LAPC [12, 13].However, abutment to the SMA was not diminished after chemoradiation therapy, and the patient was still diagnosed with UR LAPC.
Novel modalities to administer radiation therapy for early stage breast cancer have received increased attention.
As adjuvant radiation therapy is the standard of care for women who had undergone lumpectomy, the participants were also asked if they would administer radiation therapy to the elderly patient.
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There are several lines of evidence that early (concurrent) radiation is superior to late (sequential) administered radiation therapy (Murray et al, 1993).
An additional advantage of administering radiation therapy synchronously with chemotherapy is the shortening of the overall duration of treatment without a substantial increase in toxicity [ 18].
Due to the high locoregional recurrence rate that TNBC shows, we selected to administer concurrent radiation therapy with CMF-based chemotherapy, a strategy whose rationale is supported by recent studies demonstrating that the magnitude of benefit of CMF chemotherapy is largest in patients with triple-negative, node-negative breast cancer [ 37].
When Randi Gaier, a 34-year-old mother of two preschoolers in Wynnewood, Pa., was treated for Hodgkin's disease 15 years ago, surgeons first moved her ovaries out of the radiation field before administering the radiation therapy that cured her.
The standard radiation dose is 50.4 gray (Gy) in 25 fractions with a cisplatin/5-fluorouracil (5FU) regimen, two cycles being administered during radiation therapy and two more cycles given after completion of the radiotherapy (Cooper et al, 1999).
In this report, we describe a novel technique used to plan and administer external beam radiation therapy to a patient in the upright position.
In the era of precision medicine, the lack of -omic determinants of radiation response has hindered the personalization of radiation delivery to the unique characteristics of each patient׳s cancer and impeded the discovery of new therapies that can be administered concurrently with radiation therapy.
We treated the patients using CRT with S1 at a radiation dose of 1.8 Gy/fraction given five times weekly (Monday to Friday) to a median dose of 59.4 (45 to 59.4) Gy; S-1 (80 mg/m2/day) was administered orally during radiation therapy.
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