Centuries later, powerful rum was administered freely to British sailors before emergency amputations were carried out on board ship in the aftermath of battle.
This phenomenon is also seen in pigeons and monkeys, who repeatedly self-administer freely available ketamine, suggesting that it is difficult to control ketamine use during a binge (80, 81).
Based on the mean drinking volume of 25±3 ml/day (95% CI) of adult Sprague Dawley rats, as evaluated in about 100 animals of our previous studies, a high dosage of NAC was administered via freely available drinking water (1.4 g/kg of body weight/day; ACC 600, Hexal AG, Holzkirchen, Germany) in the NAC+ subgroups from surgery until killing.
Drugs, too, are scarcely unfamiliar: laudanum - an opium derivative, often mixed with alcohol - brought relief from poverty and pain in the 19th century and was freely administered to children to pacify them.
In vitro cytotoxicity studies on two cell lines (OCI-AML3 and THP1) demonstrate that FLT3-loaded GNP are promising candidates as vehicles for anti-tumor drugs and show superior therapeutic effect than the freely administered drugs.
Agents were administered into a freely running intravenous line.
An online survey was administered electronically via freely available software (http://www.surveymonkey.com).com
The PK model developed by Stevens et al. (2011) shows the added value of separation and quantitation of systemic and direct nose-to-brain transport after IN administered remoxipride in freely moving rats, in terms of extent and rates (34).
These could be avoided if magistrates, who give their time freely to administer the law, had discretion over the charge and its application – using their skills, built through experience and training, to arrive at just outcomes.
7 Patients are taught carbohydrate counting and insulin dose algorithms, which enable them to eat freely and administer a dose of insulin that matches the intended meal.
Both Muslims and Jews were required to pay a regular tribute, but otherwise they were allowed to worship freely and to administer their own affairs according to Islamic or Judaic law.
