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During each vaccination, the same adjuvant without any antigen was used as sham control.
Development of a potent vaccine adjuvant without introduction of any side effects remains an unmet challenge in the field of the vaccine research.
Attempts to dry coat alum adjuvant without excipient resulted in minimal vaccine coating on needle tips, and crystallization of the alum adjuvant (Figure S1).
Challenge infection with this parasite line has proven highly virulent in Aotus nancymaae over the course of numerous studies, requiring treatment in all control animals administered complete Freund's adjuvant without a blood-stage vaccine antigen (n = 55, Table S1 and Supplemental Information).
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As HPV-L1-VLPs are highly immunogenic even without adjuvant, formulations without alum will also be investigated.
Furthermore, minimal immunological reactions were observed when the collagen solution was injected in mice treated with or without adjuvant therapy, without significant dilution of the sera [ 50].
The model thus predicts HRQoL in women treated without axillary clearance, without adjuvant systemic therapy, without regional radiotherapy, and with few co-morbidities after radiotherapy.
However, patients who underwent SLNB were more often treated with conservative surgery, without adjuvant chemotherapy and without adjuvant hormone therapy.
Adjuvant chemotherapy without anthracycline was administered because of the patient's hypertension.
While uncontrollable malignant tumors contraindicate liver transplantation, it may be difficult to continue adjuvant chemotherapy without controlling the patient's CTLN2 symptoms.
All patients received adjuvant tamoxifen, without adjuvant chemotherapy.
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