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After a number of dose adjustments this method of individualising dose gave a three-fold interpatient range of cyclophosphamide dose (450 to 1800 mg m) and a four-fold range for epirubicin (38 to 120 mg m).
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A permanent application (and site-specific adjustment) of this method, and the use of the resulting teaching tools, could reduce social vulnerability and empower indigenous communities in the development of volcanic risk mitigation strategies by revitalizing and sharing knowledge, rather than imposing one epistemological system onto the other.
However, the theoretical potential to perform the proposed adjustment suggests that this method possibly might provide a quantitatively or qualitatively accurate estimate of an unconfounded treatment effect in circumstances in which instrumental variable analysis may not be possible.
Over the decades, many adjustments and variations of this method have been employed and the future utility of the STRIP distillation method, especially in the field of sulfur (isotope) biogeochemistry remains strong and promising.
By using this method, adjustments were made for the opportunity cost of the production the individuals could have contributed with if they had been at work [ 19, 21, 26].
The example presented in Fig. 7 illustrates the generation of synthetic random activities by employing the adjustments factors previously calculated; through this method the Beta PDFs are acquired with the characteristics of the desired family of curves from the original earth-moving operations.
This method facilitates adjustments for possible confounders and straightforward modeling of effect modifiers, as opposed to Edwards' model [ 10].
However, to estimate total residual confounding through this method, such adjustments must occur to two quantities: 1) the change in the treatment effect estimate between Model 1 and Model 2, and 2) the Model 1 treatment effect estimate.
This dependence limits the applicability of this adjustment method and increases the uncertainty and construction risks during the drilling process.
The process of bias-adjustment, at the heart of this method, relies on expert opinion and might be considered to be somewhat subjective.
This method of adjustment was performed to compare over time the results of prevalence surveys conducted in the region of Bizerte (northern Tunisia) for seven years (2005-2011) atwowo regional hospitals 691 beds comprising 17 hospital services.
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