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The two year follow-up will allow for a prospective evaluation of these patients during multiple adjustments of therapy.
In direct contrast other trials were designed to do less self monitoring and more self-care, while adjustments of therapy were minimal[ 38].
The conclusion from the BeSt study is that, with intensive and objective monitoring of disease activity and adjustments of therapy, low disease activity is a realistic goal that can be achieved with all treatment strategies.
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More recently, adjustment of therapy based on incorporation of post-treatment data is likely to become increasingly important.
The clinical benefits (adjustment of therapy for bacteria not targeted empirically) were more limited as only 7 patients were affected and adjustment was delayed by 2.4 days on average.
Adjustment of therapy intensity based on the results of [18F]FDG PET interim staging is of special interest, e.g. for reducing chemotherapy-related toxicities, but is currently not used in clinical routine in non-Hodgkins' lymphomas due.
Information systems that permit tracking of outcomes and adjustment of therapy [ 35- 39].
Therefore, a new adjustment of therapy with MBV (400 mg p.o. twice per day) was initiated.
Individualized adjustment of therapy was based on the T2T strategy and patient's willingness.
Thus, interventions aiming at improving antibiotic prescribing should focus on both initial empirical therapy and streamlining and adjustment of therapy.
The switch of the same antibiotic from i.v. to p.o. was not considered to be an adjustment of therapy.
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