Exact(1)
No dose adjustments of the study medication were planned.
Similar(59)
Increasing number of participating hospitals in each country required adjustment of the study procedures to suit each hospital situation without compromising the integrity of the study.
This involved the structural adjustment of the study sample to the population level whilst maintaining the case base of participating children, ^ The limitations outlined in this table were identified by the authors of this systematic review during critical appraisal of each study.
Three additional visits including clinical assessment and blood and urine chemistry will take place at month 9, 15 and 18. Patients in the treatment arm will have four extra visits at week 2, 4, month 1 and 2 after randomisation to allow for blood level monitoring and potential dose adjustment of the study medication.
Although, the precision of adjustment varied from study to study as seen in the detailed adjustment column of the study table, in essence the estimates provided in this meta-analysis represent the direct effects of the diseases adjusted for smoking status.
If the results are positive, the website http://www.wiagesprek.nl may be implemented nationwide after possible adjustments on basis of the study's conducted process evaluation.
Because most neoevolutionists are interested in the environmental and technological adjustments of the groups they study, many are identified with the cultural ecological approach to ethnography, with the culture process approach to archaeology, and with the study of early and protohumans in biological anthropology.
Forty-two percent of children received dose-optimization adjustments during the study, most of which were dose increases (38% of subjects) [ 46].
Thus, in addition to adjustment for day of the study, day of the week and calendar holidays, total hospital admissions for children ≤18 years old were also considered as a proxy for the population denominator.
Assessment of adjustment in the study was limited to self report and some children may have selected socially desirable responses, rather than reflecting on their own behaviours.
Dose adjustment at randomisation or maintenance-dose adjustment during the course of the study did not occur during the EINSTEIN, AMPLIFY (NCT00643201), RE-COVER, RE-MEDY (NCT00329238) or RE-SONATE (NCT00558259) studies [ 20– 27, 27].
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