It has been shown that new activity can be introduced by simultaneous incorporation and adjustment of functional elements through insertion, deletion, and substitution of several active site loops, followed by point mutations to fine-tune the activity [ 73].
Further adjustments for number of functional limitations, education in years, monthly income, cognitive functioning and depression had no effect on the results (Table 3).
We could not make adjustments for functional limitations owing to lack of information in the database.
Furthermore, apart from Anderson et al., authors of the arthrodesis studies did not describe adjustment of the functional score to the normal loss of motion after fusion of the talocrural joint, which makes it a non-uniform scoring system [ 24].
When studying the effectiveness of treatment, adjustment for functional and cognitive status may yield more valid results than controlling for comorbidity alone.
Although old people wearing dentures present similar patterns of functional adjustments to food consistency with dentate persons, indicating that the role of periodontal ligament mechanoreceptors is taken over by other receptors (Karkazis and Kossioni 1998), their masticatory performance differs in some respects.
A higher number of environmental barriers indoors showed a slight protective effect against mortality even after adjustment for functional limitations (RR 0.98, 95% CI 0.96-1.00).
Unexpectedly, the results indicate that a high number of environmental barriers indoors have a slightly protective effect against mortality risk, even after adjustment for functional limitations.
The NIS has potential to provide useful information for case-mix adjustment and as a predictor of functional gain in general neurorehabilitation settings.
Wrist fracture remained an important predictor of functional decline after adjustment for age, body mass index, health status, comorbidities, and neuromuscular function (odds ratio 1.48, 1.04 to 2.12).
