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In terms of next steps a randomised trial addressing the hypothesis that a strategy of escalated ABVD with early biomarker-driven adjustments of dose is more effective than standard ABVD is currently under consideration by the UK NCRI Lymphoma Clinical Studies Group.
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55 Three masters level and two doctoral level health psychologists administered behavioural migraine management in four sessions of one hour each at the four monthly clinic visits also used for adjustments of doses of drugs.
Adjustment of dose for differences in body weight had minimal impact on these results.
A main purpose of tube current modulation is the adjustment of dose exposure to body anatomy, yielding almost constant image noise along the scan [13, 14].
After adjustment of dose by weight and by BMI, the compartmental model was used to simulate plasma concentrations and new values for Cmax and AUC0 24.66 were calculated.
This observation is particularly interesting in that others have noted a strong correlation between maximum prescribed dose of phenytoin or carbemazepine in epilepsy and genetic variants in CYP2C9 or SCN1A, suggesting clinical adjustment of dose in response to genotype [44].
Our protocol permitted body-weight-targeted adjustment of dose of diuretics.
In liver impairment, adjustment of dose may be required, though no specific guideline is available.
Such modification may be adjustment of dose, addition of another treatment (combination therapy) or switching to another therapy.
Mice were weighed on each treatment day prior to injection to enable the adjustment of dose per individual body weight.
It involves evaluation of symptoms, follow up of effect, adjustment of dose and monitoring over time as well as deprescribing when indicated [ 21, 28, 36].
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