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However, considering the number of observations (77), the number of analysed terms (20), the number of lags included in the transfer functions (12) and seasonal adjustments, it is difficult to exclude the possibility that the low number of statistically significant connections at specific lags may result from statistical error.
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The visual system has a large variety of adjustments, and it is difficult to define adaptation in a way that it can be clearly distinguished from other forms of plasticity [ 43].
Although this adjustment may be correct, it is difficult to implement in replicating the Trasande analysis, so it is not included in future discussions.
Since their study sample was relatively small (n = 86) and that no adjustments for sex were performed, it is difficult to clearly delineate the direction of the relationship between LINE-1%meth and MetS-related phenotypes.
A further important concept is the need to adjust insulin treatment prospectively rather than falling into the trap of "reacting to numbers" with frequent between-meal corrections and such continual adjustment of basal rates that it is difficult to determine actual requirements.
At that stage it is difficult to make adjustments or consider alternatives.
Therefore, it is difficult to implement risk-adjustment methods based on these data in a systematic way [ 5, 10].
When you see the big picture, it helps you move from feeling overwhelmed to understanding that this is a temporary adjustment, and while it's difficult now, you are willing to go through some uncertainty and discomfort for the long term gain. 5.
15 Previous studies have shown that the DSP system has high rates of missing data among children under 5 years of age, and even with adjustment using under-reporting rates, it was difficult to retrieve good-quality data.
As for the oft-heard suggestion that making in-game adjustments is difficult, Francois wasn't having it.
In addition, the diagnosis of adjustment disorder is difficult to determine, and it has been described as a 'waste basket diagnosis'.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com