In particular, this approach can be used to support dose adjustment in specific subgroups of a population.
In these circumstances, it has been demonstrated that the use of pharmacokinetic pharmacodynamic relationships in conjunction with M&S concepts can support dose rationale as well as dose adjustment in specific subgroups of a population.
Existing data indicate that the effect of CR on the aging process might be mediated by a reduction in glycosylation and hormetic responses [ 21], oxidative damage, metabolic adjustments or changes in specific gene expression [ 22].
However, the upper working limit of solids concentration in a plant may also be limited by enzyme inhibition and hydrolysate toxicity to the fermenting organism, so there may be room for adjustment in a specific process to incorporate solids recycle.
The data generated by the system is handled primarily in the QGIS platform, for database adjustments and handle graphics in specific periods of time and locations.
It has been suggested that service firms face a higher level of customer contact which requires specific adjustments in organizational design.
In the following, we present four different examples in which the STRIP method can be used, and highlight specific adjustments in the methodology that have to be made for obtaining an optimal outcome.
However, the specific adjustments in muscle activity patterns during HIE practices, as presently observed in the field (e.g., training [ 10] or games [ 4]) are still unknown.
However, this assay is not capable of differentiating among lower quality FFPE DNA templates (that is, QFI <3 to 6%), nor can it prescribe specific adjustments in DNA input that may help offset the deleterious effects of poor functional quality.
Although our understanding of how these experience-dependent changes are orchestrated at the molecular level is far from complete, it is clear that adjustments in the levels of specific gene products is necessary.
