Each method of adjustment trial commenced with a beep.
We did sensitivity analyses by applying continuity adjustment in trials with zero events.
The dose of the usual antidiabetic medication will be individually adjusted parallel with the dose adjustment of trial medication to ensure optimal glycaemic control.
Results were similar and trial groups were combined into a single cohort with adjustment for trial group.
However, the intervention (trial arm) was not associated with any of the measures of parental or childhood adiposity at 6.5 years.[19] Associations without adjustment for trial arm were essentially the same as those presented.
Randomization produced nearly identical distributions of demographic and reproductive characteristics between arms, and further adjustment for trial arm did not change any results (data not shown).
The individual dose adjustment of trial medication and ongoing antidiabetic treatment will ensure that randomisation to the two placebo groups will not cause deterioration of glycaemic control during intervention.
Adjustments for trial differences will be made by including the trial variable in the model specification.
The same model was applied for the absolute trial-by-trial adjustment of time estimation as dependent variable.
Means and standard deviations for time estimation and absolute trial-by-trial adjustment in time estimation data are presented in Table 2 for all conditions.
