In the case of safety biomarkers, we wanted to retain the null hypotheses, therefore the use of a more stringent Bonferroni p-value adjustment threshold (p-value <0.0023) for testing 22 independent immune markers would likely be non-conservative, resulting in false negatives.
Boolean searches allow for complex query formulation, and are thus well suited to the exhaustive searching necessary for systematic reviews, but they allow no adjustment of threshold for retrieval based on probability or relevance [ 6].
To produce relative weights, stepwise logistic regression was done for each participant with adjustment of thresholds for retention of predictors - if necessary - until a solution was found in the model where regression coefficients did not have high standard errors.
There is no need for any adjustment of the threshold for significance.
A major benefit of (semi- quantitative FITsemi- quantitativetment oFITse threshold for posisivithattest characteristics and numbyr of follow-up colonoscopies cadjustmentd toflocal resources [ 10, 11].
For relatively low values of r, the relative costs of FN to FP, a threshold self-reported BMI of around 27 27.5 seem appropriate, indicating a downward adjustment of the current threshold for self-reported BMI of up to 2.5 units.
In many cases, extracorporeal CL accounted for more than 30% of the observed systemic CL for that antibiotic, which is a suggested threshold for adjustment of the dosing regimen.
To enable a less biased comparison between tissues, we sought to reduce the influence of the number of samples on the number of detected genes by a tissue-specific adjustment of the FDR threshold for significance.
Recently we have realized that for a given sample size (number of genotyped individuals), the choice of IBD scale parameter for values ≥2 is somewhat arbitrary, provided that appropriate compensatory adjustment is made to the threshold for significance of the fastIBD score or the Refined IBD LOD score (data not shown).
In order to reduce such interference, an adjustment of FDR thresholds for tissue-specific over-expression was performed for each data set independently.
