Sentence examples for adjustment of dosing from inspiring English sources

Whereas metabolic tolerance might be overcome by adjustment of dosing or administration intervals, this might not be possible with functional tolerance.

The authors concluded that CVVHF had little effect on micafungin kinetics, and no dose adjustment or modification of dosing interval was needed during CVVHF.

However, neither time until dose adjustment nor strategy of dosing modification was related to recovery of baseline renal function at the EOT (data not shown).

Adjustment of dose for differences in body weight had minimal impact on these results.

A main purpose of tube current modulation is the adjustment of dose exposure to body anatomy, yielding almost constant image noise along the scan [13, 14].

After adjustment of dose by weight and by BMI, the compartmental model was used to simulate plasma concentrations and new values for Cmax and AUC0 24.66 were calculated.

These findings supported the hypothesis that the pharmacokinetic clearance of lithium shifted with levels of emotional, behavioral, and physiological arousal and indicated that safe treatment with this potentially toxic agent required corresponding adjustment of doses and close monitoring of blood concentrations (Kukopulosb and Reginaldi 1973 Kukopoulos et al. 1985).

This observation is particularly interesting in that others have noted a strong correlation between maximum prescribed dose of phenytoin or carbemazepine in epilepsy and genetic variants in CYP2C9 or SCN1A, suggesting clinical adjustment of dose in response to genotype [44].

Our protocol permitted body-weight-targeted adjustment of dose of diuretics.

In liver impairment, adjustment of dose may be required, though no specific guideline is available.

50 Another use is the adjustment of doses where different trials have used various dosages of the same treatment.