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Some authors have argued that since PHTfree levels may not be readily available, the adjustment in cases of known hypoalbuminemia provides better guidance in dosing than the total PHT level obtained in the usual assay used for therapeutic drug monitoring [ 9, 15, 17].
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ICU, hospital and 28-day mortality and the length of stay (LOS) in ICU and in the hospital were compared between each quartile, before and after adjustment in case of differences in baseline characteristics.
* All drugs in this class require dose adjustment in case of moderate or severe renal impairment.
** Some drugs of this class require dose adjustment in case of renal impairment.
It requires an adjustment in case of reduced glomerular filtration rate.
Each time point difference between selepressin and other groups was compared with a least significant difference adjustment in case of a significant group effect and/or of a significant time × group interaction.
When comparing the five different references consulted to identify necessary drug dose adjustment in relation to the estimated kidney function, we found that the number of drugs that necessitate a dose adjustment in case of renal impairment differ considerably (Table 5).
19 Prognostic factors for the duration of sick leave (for adjustment in case of dissimilarities between the treatment groups) were potential work related psychosocial factors, measured with the job content questionnaire, 20 and data on workload, measured with the Dutch musculoskeletal questionnaire.
Parallel masitinib-treatment groups at different initial dose levels were studied to determine the optimal starting dose of masitinib, with dose adjustments possible in cases of insufficient response.
This amendment to construction law was introduced to reduce future claims for extra help for home adjustments in case of disability.
Complete medical charts were reviewed for motivations for therapy adjustments in case of guideline-discordant treatment.
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