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A balanced Latin-square design will not require adjustment for order effects; the comparison between outcomes from the different intervention conditions will not require adjustment for order effects, given the balance Latin-square design.
Additional adjustment for order of birth, however, weakened the association with time interval since most recent birth.
This effect was estimated by comparing the geometric mean change difference between treatments in the Kamut group and in the control group, after adjustment for order of treatment.
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We observed a significant positive association between number of siblings and age at menarche, which strengthened after adjustment for birth order.
Further adjustment for birth order and age at first schooling had no material effect on the observed leukaemia benzene relationship (personal exposure: OR 0.92 (95% CI 0.75 to 1.13); outdoor benzene: OR 0.95 (95% CI 0.81 to 1.13)).
However, adjustments for birth order did not modify the association and there was no interaction between the two variables.
Due to the large number of stratifier categories, there will be no adjustment for stratifiers in order to ensure that estimation of intervention effects is stable.
Since previous studies have described the existence of lifetime variation of lipid profile measures according to age (in both genders) [ 15, 16], our results of comparisons between groups were obtained with adjustment for age in order to eliminate this putative confounding factor.
However, the findings point to a need for further validation and risk adjustment in order for to support ongoing quality monitoring.
Another concern was that the MDR method did not facilitate making adjustments for lower-order genetic effects or confounding factors.
After adjustment for sibship size, birth order had a significant inverse association with age at menarche.
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