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An adjustment for low risk effects is not considered in the procedure of OECD guidelines, which is typically proposed only for the optimal determination of EC50.
Adjustment for low back pain modified the difference to an insignificant level (p = 0.119).
Results were similar after adjustment for low selenium status at baseline (P = 0.28, P = 0.67).
Results were similar after adjustment for low zinc status at baseline (P = 0.91, P = 0.51).
Significant associations persisted even after adjustment for low birth weight and duration of pregnancy, suggesting that the effect of passive smoking on asthma was independent of these factors.
All analyses were repeated with adjustment for low birth weight (<2501 g, ⩾2501 g), mode of delivery (normal vaginal, caesarean section, other), admission to special care baby unit (no+unknown, yes) and year of birth, but the findings were unchanged (data not shown).
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Additional adjustment for low-fat dairy increased the HR even further (HR, 1.38; 95 % CI, 1.10, 1.72, data not shown in tables).
Conversely, the associations with non-aspirin NSAID use were not meaningfully altered after adjustment for low-dose aspirin use (data not shown).
We additionally adjusted the associations between 25(OH)D2 and 25(OH)D3 and microalbuminuria and macroalbuminuria for the low-grade inflammation and endothelial dysfunction scores and found that these associations did not materially change after adjustment for low-grade inflammation and endothelial dysfunction (Tables 2 and 3, model 3 and 4, respectively).
The effect of other variables is shown in Table 4. Overall, patients randomized out-of-hours had a higher mortality risk (primary adjusted OR 1·47, 95percentnt c.i. 1·00 to 2·17; P = 0·048), although this reduced to borderline significance after further adjustment for lowest recorded systolic pressure and volume of fluids administered (Table 4).
Increases in the prevalence of ASD have been found by different methods, and the procedures have required adjustments for low response rate or missing data.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com