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Winton et al. (2010) argued that the decadal scale adjustment clearly contains the oceanic changes, and hence, it is more appropriate to regard the adjustment as a part of the feedback, rather than as a part of the forcing.
Moreover, although residual confounding after RUV-4 adjustment clearly remains in the gene expression data, our immunohistochemistry validation studies in independent cohorts suggest that, at least on a disease-pathway level, we have captured true biological signals.
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However, not all adjustments clearly improved the medication regimens and almost as frequently the physicians insisted on the primary (inappropriate) dosage regimen although in most cases a switch to more appropriate drugs would have been possible.
During the prescription process in response to half of the alerts (69 of 136) the prescribers made adjustments (selection of another brand, adjustment of dosage regimen) and in the overwhelming majority (87%, 60 of 69) the adjustments clearly improved the medication regimen (Table 2).
The effectiveness of the adjustment is clearly appreciated in Figure 5 that shows the globally averaged datasets from 60°N to 60°S before and after the SNN adjustment.
Both this and the former regression adjustment method clearly indicated a statistically significant effect of birth spacing on child mortality.
Risk adjustment is clearly necessary given the large differences in rates between hospital levels across all four infection outcomes (Table 1; Figure 1).
However, this does not provide us with a principal problem since the division into admission frequency classes (patient view) is along the lines of identified and distinct risk classes for which adjustment is clearly needed.
The revised figures, in which this grouping has been made explicit in the arrangement, and figure legends, in which the adjustments are clearly stated, are shown below.
Of note, recovery times were similar in both groups (1.1 to 1.3 hours), probably because of the dosing algorithm and the high frequency of monitoring and dosage adjustments, which clearly prevented over-sedation in this study.
They will be retained for adjustment if they clearly improve the model in terms of the coefficient or adjusted coefficient of determination, in the absence of knowledge regarding treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com