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This adjustment can result in more or less reported results, by favoring higher level parent nodes with more associated genes, resulting in up to an 80% reduction in the number of reported terms (Supplementary Table).
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Sometimes, small adjustments can result in a lot of change.
Omission of these factors in analytic adjustments can result in conclusions that may not accurately reflect differences in patient outcomes.
Even something as superficially straightforward as applying the exclusion criteria for a risk adjustment method can result in varied interpretation [ 45].
Among many others, Wittes [ 44] states that lack of adjustment can lead to a misinterpretation of the study results as well as Bonferroni adjustment can do.
Lack of adjustment for this confounding can result in primary care trusts and general practitioners being penalised for patterns of service use that they cannot directly control [ 2].
Estimating the direct effect of temperature on asthma emergency department visits is not the objective of this analysis and would require statistical adjustment for each of these intermediate variables, which can result in over-adjustment bias and is inappropriate if the mediator is an effect measure modifier [ 24, 25].
"The international monetary system has a structural flaw: it lacks a mechanism, market based or otherwise, to induce needed adjustment by surplus countries, which can result in persistent imbalances," repeated Bernanke, making no reference to deficit countries, the other side of the imbalance.
Controlled by 60 sliders, each of which influences one part of the face's characteristics, Woodly refers to the synthesizer as 60-Dimensional Face Field, a space in which even small adjustments to a few sliders can result in dramatically different facial features.
The reason for this discrepancy is likely multifactorial as these reports differ in terms of their design and study populations, as well as their choice of variables for which adjustments were made, many of which can result in considerable confounding if not properly adjusted.
Catheter perforation can result in dose adjustment problems, or even in a severe withdrawal syndrome [38].
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