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Without any adjustment, a threshold of 5.2% was calculated; with adjustment for age, sex, and blood pressure, the threshold was 5.6%, and after a more comprehensive adjustment, the cutoff was 6.0%.
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A multiple testing adjustment (FDR) (Benjamini and Hochberg 1995) at a threshold of P ≤ 0.01 was applied across all SNPs and joint probabilities collectively using the " P-Value Adjustment" of JMP Genomics v7.1.
Significance was measured for mean expression (against all shared orthologs) by two-sided t test, and for the number of genes up or downregulated at an absolute log 2 ratio of 0.5 by Fisher's exact test (in both cases, at a threshold of P < 0.05 after adjustment for multiple testing by the false discovery rate method of Benjamini and Hochberg).
He has a threshold of one.
A threshold value is set for each class, which triggers dynamic weight adjustment whenever a threshold is exceeded.
After a strictly conservative adjustment by Bonferroni, a significance threshold of P ≤ 1.7 × 10−8 would have been required to claim genome-wide significance, which was not reached in this study.
By combining statistics and manually interactive adjustment, the thresholds of silt contents for categorizing different degraded lands were determined as 3.5% and 8.8%, and it can effectively detect the degraded areas from others; total classification accuracy of this approach reached 86.21%.
The main novelty of the method are: (1) Intelligent data analysis and monitoring, without a threshold adjustment; (2) Fast identification of an internal fault conditions and high coverage of turn-to-turn faults; (3) Secutity during transients such as inrush currents, external faults and overexcitation; (4) Simplicity.
Specifically, we did not find significantly deregulated miRNAs using a significance threshold of 0.05 after FDR adjustment.
Cox regression analysis (Wald test) was applied to the 17 870 genes using a FDR threshold of 1% after adjustment for testing of multiple hypotheses.
In addition, we repeated the comparison of Wilms patients before and after therapy using all 43 samples and applying unpaired two-tailed t-test, which confirmed the results of the matched samples (no significant miRNA using a significance threshold of 0.05 and FDR adjustment).
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