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The results confirmed the utility of adjusting dosing to clinical presentation, which is typical of clinical practice.
5 Future evaluations to assess the incremental cost of optimizing IVIG therapy (eg, adjusting dosing and/or achieving sustained steady-state levels) should include an evaluation of the effects on infection-related medical expenditures.
Based on standard clinical practice of adjusting dosing to muscle mass, investigators examined the results of varied dosing in male and female subjects (50, 60, 70, or 80 U). 63 The overall responder rate based on the blinded evaluator assessment at day 30 was 85%.
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Leslie V. Norwalk, the acting administrator for the Centers for Medicare and Medicaid Services, said she supported combining drug and dialysis payments but said current policy gives physicians flexibility to monitor patients and adjust dosing.
The question then arises whether TBW, which is commonly used to adjust dosing in children and adolescents, is the appropriate measure to adjust doses of drugs in obese children and adolescents.
Currently, peak and trough concentrations are used to adjust dosing to minimize chances of toxicity under the hypothesis that toxicity is concentration dependent (14).
Dialysis centers across the nation are now checking bicarbonate levels in patients and adjusting doses if necessary.
However, the clinical impact of adjusting doses of NMBAs according to the TOF is still a matter of debate.
Although clinical trials have found that enoxaparin clearance is prolonged in renal impairment, only one letter describes experience with adjusting doses.
Simultaneously adjusting dose for duration did not materially alter the observed associations (data not shown).
In a sense, switching treatment, adjusting dose, and discontinuing a patient involve decisions that may cause selection bias.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com