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For simulation #1, Figure 1 compares slope estimates versus, the SVA-adjusted variant of versus and versus, on each of the m = 1000 features.

18 The age-adjusted variant of the CCI was not used, because our study population contained only patients aged over 90 years.

The seasonally-adjusted variant of the algorithm used transformed notification data: X i * = Y j, m S j, where Y j, m was the number of notifications in week j (j = 1,...,52) of year m (m = 1,...,17), i = 52 m-1)+ j, and S j = 1 17 Σ m = 1 17 Y j, m 1 SS 4 Σ m = 1 17 Σ j = 1 S 2 Y j, m.

Then, the accurate segmentations between connected or overlapped characters are adjusted by a variant of A∗ path-finding algorithm at the second stage.

Conditional analyses, where the association between a genetic variant in one gene is adjusted for variants located in the other genes, can help understand the complex picture by disentangling the effects of correlated gene variants.

To evaluate the proportion of variation of FC tests explained, the coefficient of determination (Multiple R-squared) and its variant adjusted for the degrees of freedom, were evaluated for the complete model as well as for the model selected by minimum BIC.

Considering the number of reads supporting each rearrangement breakpoints and adjusting this value for both copy number and ACF, we were able to estimate the adjusted variant allelic frequency (VAF) of each rearrangement VAF.

Panel 1 is the histogram of absolute values of adjusted differences between reference and variant allele read counts (variable name is "y"), with bar width = 1.

Within each haplotype, we also estimated the effect in terms of odds ratio of each sole variant in Class I adjusted for the effect of the sole variant in Class II loci versus all the other variants in Class I also adjusted for the effect of the sole variant in Class II loci, by fitting a model including both the sole variant in Class I and the sole variant in Class II.

Analysis of variance (ANOVA), Tukey post hoc analysis and t-test were applied to test the differences of obesity-related anthropometric and metabolic traits across genotypes of rs9939609 variant adjusted for age and sex.

Furthermore, we observed an increased risk of glioma occurrence associated with the GPX1 rs1800668 variant (adjusted OR = 1.18; 95% CI = 0.82 1.69).

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