The age and sex adjusted interaction between DM and CVD in predicting mortality was highly significant (p = 0.002) and persisted after accounting for comorbidities and treatment factors (p = 0.006).
fully adjusted interaction models.
The adjusted interaction p value is p = 0.0878.
18 Fully adjusted interaction terms are illustrated using predicted means or probabilities and 95% CIs.
Race by neighborhood poverty interactions (p < .001) were evident for both outcomes in the final adjusted interaction models (Model 6).
We could not detect a difference in the effect of surgery between the groups (adjusted interaction P value = 0.713).
Both partially adjusted and fully adjusted interaction models, however, showed no significant variation in BMI during early childhood by mild or moderate/severe depressive symptoms (Table 1).
The analysis resulted in four models each for child height and BMI trajectories: Model 1a, c) partially adjusted main effect models; Model 1b, d) fully adjusted main effect models; Model 2a, c) partially adjusted interaction models; and 2b, d).
After 15 years of follow-up, bariatric surgery reduced the cumulative incidence of diabetes in both the noneligible (adjusted hazard ratio 0.33 [95% CI 0.13 0.82], P = 0.017) and eligible groups (0.27 [0.22–0.33], P < 0.001), and the treatment effect on diabetes incidence was not significantly different between the groups (adjusted interaction P value = 0.713) (Fig. 1).
There was a borderline significant difference in mortality reduction with CRT-D in patients with ischaemic cardiomyopathy compared with those with non-ischaemic cardiomyopathy (unadjusted interaction P-value = 0.099, adjusted interaction P-value = 0.153), suggestive of an incremental beneficial effect of CRT-D over CRT-P in ischaemic patients, but not in patients with non-ischaemic cardiomyopathy.
Significant group by time interaction effects were examined using sets of Bonferroni adjusted interaction contrasts to compare between-group differences in mean change on the outcome measure from baseline to post-intervention (i.e., intervention period) and from post-intervention to follow-up (i.e., follow-up phase), as appropriate.
