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For eQTL analyses, the gene expression trait values were first pre-adjusted with gender as a covariate in a linear model and the gender adjusted gene expression trait residuals used as the dependent variable in the QTL mapping.
The similarities between the mouse and human tumors are also highlighted by the gene expression microarray studies which found a 68.1% Pearson correlation in quartiled and grade adjusted gene expression.
The same t-test was repeated using the various empirical Bayes batch adjusted gene expression values.
To account for natural variation between mouse strains, we adjusted gene expression level in infected mice for gene expression level in uninfected mice.
Additional file 6: P-values and Benjamini and Hochberg False Discovery Rate (FDR) values associated with model-estimated fold changes in Additional file 7. Additional file 7: Normalized, model adjusted gene expression and log2 fold changes for all genes tested for differential expression (DE).
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To overcome this problem, dynamic regulation is desired to adjust gene expression and metabolite concentrations to desirable levels, thus reducing cellular stress and avoiding waste of carbon and energy.
Technical noise may be modeled with a log-normal function to adjust gene expression estimates.
Translational control is widely used to adjust gene expression levels.
Acting predominantly through gce, JH also adjusts gene expression in ECs to support increased lipid metabolism.
Living cells must be able to correctly respond to internal and external stimuli by adjusting gene expression levels [ 1].
Interestingly, epigenetic mechanisms seem to allow an organism to respond to environmental changes by adjusting gene expression [ 4].
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