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Neutropenia was independently associated with poor outcome when adjusted for underlying malignancy, allogeneic stem cell transplantation and severity as assessed by organ support (OR 1.45; 95% CI 1.27 1.65).
The association between overall mortality and increasing age remained highly significant when adjusted for underlying co-morbidities or immunosuppression (p = 0.001).
When adjusted for underlying disease, receipt of these chemotherapeutic classes were still predictive of mortality.
37 38 39 40 The number of patients included in the study enabled analyses to be adjusted for underlying disease and other potential confounders such as drug prescriptions.
Adjusted for underlying diagnosis, age, gender, serum creatinine, N patients with ≥1 prescription exceeding recommended maximum or standard dose at baseline.
It is difficult, however, to disentangle the impact of these measures from other concomitant quality initiatives, because few studies have adjusted for underlying trends in quality of care.
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When adjusting for underlying disease, this relationship did not change.
Although some studies do not adjust for underlying trend, most of them do adjust for a linear one.
This analysis is able to adjust for underlying differences between groups, but it suffers from some degree of missing data.
Indeed, failure to adjust for underlying differences in cofactors could have given an exaggerated picture of differences between the sexes.
The m-CCI enabled us to adjust for underlying diseases, and the large study size provided statistical precision for the estimates.
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