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Most methods (see paragraph below) have focused on threshold adjustments and adjustments of the P-value, but adjusted confidence intervals can often be calculated based on an adjusted P-value and an effect estimate, as well as adjusted P-values can often be calculated based on adjusted confidence intervals and an effect estimate [ 14, 49].
Most adjustment methods have focused on adjustments of the P-value threshold, but adjusted confidence intervals can often be calculated based on an adjusted P-value and an effect estimate [ 12, 35, 36].
Non-inferiority/superiority testing was carried out using the two-sided 95%% adjusted confidence limits and the margin of 4.45 N or 1.0 lb force or 454 gram force.
bBonferroni adjusted confidence intervals, P = .016.016
"caCl" means cluster adjusted confidence interval.
Thus, adjusted confidence intervals are more conservative than unadjusted.
Similar(33)
Different statistical methods have been proposed to adjust confidence intervals and P-values when multiple outcome comparisons are used [ 12].
In a secondary analysis we used a mixed-model to adjust confidence limits for possible correlations within study sites and to incorporate the T3 data [ 22].
In the absence of correlation among observations from adjacent households, an exchangeable correlation structure was assumed to adjust confidence intervals for repeated observations from the same household.
These independently derived similar patterns in enrichment and depletion support our predicted functional associations, even though experimentally verified associations, as present for other species, would provide a superior benchmark set to adjust confidence levels and assess the predicted associations.
Crucially, if the clustering is informative – the factor "works" through its clustered occurrence (such as characteristics of the agency supplying food aid to that cluster) – we would be losing information by simply adjusting confidence downwards without reassessing the risk estimate.
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