Generalized linear mixed regression models were used to adjust trend analysis for relevant confounders.
Observed and adjusted trends by period.
Observed and adjusted trends (time modelling) Fig. 138 (abstract A1153).
We tested crude trends by Spearman's rank correlation test and adjusted trends by multivariable regression analyses by entering PFOA and PFOS as continuous variables in the model.
45 Moreover, we adjusted trends for background changes in non-MVR injury admissions, which would have been most affected by changes to ED department waiting times.
In our study, adjusted trends were in several cases attenuated compared to unadjusted trends, so failing to adjust for missing data may have exaggerated the magnitude of behaviour change.
Although unadjusted trends in prevalence of IFG and diabetes in both males and females were similar to that of adjusted trends, there were slightly higher OR in each study period.
Reanalyzing the age, sex, and comorbidity adjusted trends for mortality only occurring before discharge demonstrated the same reduction in inpatient mortality as in the main analysis (nonvariceal average annual adjusted mortality OR, 0.97; 95% CI: 0.97 0.98).
This reduced the number of subjects contributing to the fully adjusted trend model from 12,696 (former smokers excluded) to 12,415 and mildly strengthened the observed effect modification by alcohol consumption with % changes per 10 additional cigarettes per day of 0.78, 4.02, 6.28, 4.81, 7.81, and 9.15 with increasing alcohol consumption intensities (interaction P = 0.0067).
The increase in the incidence of this subgroup (adjusted trend IRR, 1.10 (1.09–1.11), P<0.0001) was greater than that for CD overall.
