LR developed the adjusted profile h-likelihood.
edgeR estimates a common dispersion based on the Cox-Reid adjusted profile likelihood and then applies an empirical Bayes method to estimate the per-gene dispersion [ 12, 26].
The dispersion components are estimated by maximizing the adjusted profile h-likelihood (21) where H is the Hessian matrix of the h-likelihood.
The h-likelihood concept can be applied when using DHGLM [ 35], in which the adjusted profile h-likelihood (APHL) is used to assess the significance of variance components.
As an indication of poor model fit, implementation of the animal model DHGLM gave a lower adjusted profile h-likelihood (see next section "Model selection") than an animal model without heterogeneity of residual variance.
Here, we showed that the adjusted profile h-likelihood (APHL) can be approximated from REML-output and used in combination with AIC to provide an efficient model selection tool.
The adjusted profile for older adults using a walking aid suggests that their lower overall physical activity may be partly attributable to the lack of a second activity peak in the afternoon.
The h-likelihood itself is not an approximation but the adjusted profile h-likelihood given above is a first-order Laplace approximation to the marginal likelihood and gives excellent estimates for non-discrete distributions of y.
The algorithm that can be used for mass data processing turns into the hot research point of anomaly detection, to form normal behavior profile on the audit records and adjust the profile timely as the program behavior changed.
The study shows for the first time that AM of porous Mg may provide distinct possibilities to adjust biodegradation profile through topological design and open up unprecedented opportunities to develop multifunctional bone substituting materials that mimic bone properties and enable full regeneration of critical-size load-bearing bony defects.
Equation (5) is very versatile: when α < 1, it can adjust the profiles of potential responses; when α = 1, a first-order kinetic is described; when α > 1, a variety of sigmoidal profiles are produced.
