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However, we did adjust for major lifestyle factors, such as alcohol, smoking, income, and BMI, in the analyses.
Two previous meta-analyses found that diabetes is a stronger risk factor for CVD mortality in females than in males; however, studies that did not adjust for major CVD risk factors were included in these meta-analyses (18, 19).
Although an explanation of this paradox is not immediately clear, most of the studies have included either a heterogeneous population of obese critically ill patients or have failed to adjust for major confounding factors, such as sepsis interventions [ 11, 12].
Furthermore, we were able to adjust for major recognised risk factors for endometrial cancer, and the study has generated results on other endometrial cancer risk factors that were in line with other investigations (Parazzini et al, 1991; Zucchetto et al, 2009; Rosato et al, 2011), providing assurance that major biases were not operating.
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Historically, it turns out that Andersen's clients had less volatile returns than those of other companies, even after adjusting for major differences in industry composition.
Multivariable regression coefficients for each snoring category were calculated for systolic and diastolic blood pressure, and their odds ratios (ORs) and 95% confidence intervals (95% CIs) for hypertension were calculated after adjusting for major confounding factors.
After adjusting for major diet and lifestyle factors, the researchers found that the more SSBs a person drank, the more their risk of early death from any cause increased.
The objective of this study was to investigate the influence of age on the obesity mortality association in men and women, and to assess if adjusting for major confounding factors altered the age-dependent trend of the obesity mortality association.
American Indian/Alaska Native (AI/ANs) male veterans have considerably higher postoperative mortality rates than their Caucasian counterparts, but similar postoperative morbidity rates even after adjusting for major preoperative risk factors.
These curves were then adjusted for major changes in the shipping industry (e.g., adding the depressing effect of the growing oil glut, taking out of these historical trends the unnatural demand growth that had been caused by the Falklands war).
In the current study, the association between ctDNA levels measured by average VAF of clonal mutations and survival held true in multivariate analyses after adjusting for major prognostic factors including stage, age, and tumor burden (Supplementary Data 5), suggesting that genomic subclonal architecture may provide important prognostic information independent of these factors.
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