The mean dosage of adjunctive aripiprazole was 9.9 ± 3.2 mg/day.
However, absenteeism was significantly higher in those who were prescribed compared with those who were considered for an adjunctive antipsychotic (prescribed: n = 154, mean 12.2 days/month versus considered: n = 128, mean 9.3 days/month; P < 0.05).
Additionally, the number of days/month during which patients did not perform their usual daily tasks at their usual level (presenteeism) was significantly higher in patients prescribed than those considered for an adjunctive antipsychotic (prescribed: n = 376, mean 17.4 days/month versus considered: n = 317, mean 13.9 days/month; P < 0.05).
Weight reduction, achieved through dietary means alone or with adjunctive medical or surgical intervention, improves glycemic control and other cardiovascular risk factors.
In addition, statistically significant differences in favor of adjunctive armodafinil were observed for the mean change from baseline in CGI-S rating for depression at week 6 (P < 0.03), week 8 (P < 0.02), and endpoint (P < 0.04) and in mean change from baseline in GAF scores, indicating improvement in patient functioning, at week 4 (P < 0.02), week 8 (P < 0.002), and endpoint (P < 0.01).
All other studies investigated various combinations of PFMT and adjunctive therapies in women with a mean age 46 56 (range of 18 80).
On the SDS, ADT-Worseners receiving adjunctive aripiprazole and placebo showed a mean change from baseline to endpoint of −1.5 and −1.2, respectively.
42 In addition to HbA1c reduction with adjunctive therapy, weight reduction of a mean of 1.75 kg (CI −2.15 to −0.88 kg) or 1.8% reduction occurred in the exenatide group.
In this article, we aimed to assess the efficacy of adjunctive administration of nutritional supplements to antidepressants by means of a systematic review and meta-analysis.
