The principal mechanism of death or neurological devastation leading to withdrawal of care was identified by adjudication of the study and clinical team after review of all pertinent clinical and radiographic findings.
Despite methodological differences across studies, the adjudication of a specific SCD definition, such as in 'established SCD' used in our study, is likely to provide a most accurate estimate of SCD incidence and thereby reduces both over- and under-diagnosis.
In phase 2, the external medical monitor will assist the study with adjudication of severe adverse events on a case-by-case basis.
This has had implications for adjudication of MIs in the Rotterdam Study.
Bacterial pneumonias are heterogeneous, and the details of the case definition and adjudication of the phenotypes in these types of studies are critical components of the study design.
This approach has tended to delay the final analysis and dissemination of study results, which rely upon timely adjudication of outcomes.
The strengths of the PROBE design are randomization, prospective follow-up, and a rigorous evaluation of study endpoints by a blinded, independent, expert adjudication committee (16).
Large multicentre blinded imaging study with independent adjudication of clinical outcomes.
Independent adjudication of the definition of sepsis used in studies was undertaken in 17/57 (30%) of studies.
At the end of the study an independent blinded adjudication of relevant clinical outcomes will be conducted.
