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Arguably, such a theory might be adequate to deflect the challenge to the political legitimacy of adjudication based on the indeterminacy of law, but does it provide the normative guidance to judges we want from a theory?
Disease event ascertainment involved physician adjudication based on the review of pertinent documents at each clinical center, and further adjudication by a central committee [ 20] with agreement rates of 90% for MI and 97% for death due to coronary heart disease, between local and central adjudication.
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Adjudication of the final diagnosis was performed centrally in a core laboratory (University Hospital Basel) and included levels of Roche hs-cTnT to take advantage of the higher sensitivity and higher overall diagnostic accuracy offered by hs-cTn assays (which allows the additional detection of small AMIs that were missed by the adjudication based on conventional cTn assays).
For the 12 studies prospectively adjudicated by MHI, the sponsor identified potential cases for adjudication based on AEs and SAEs with PTs that correlated with the following Standardized MedDRA Queries (SMQs) groupings, as defined by the current version of MedDRA: "ischemic heart disease" (adjudicated for possible MI) and "cerebrovascular disorders" (adjudicated for possible stroke).
In anticipation of this limitation, we have developed guidelines to standardize adjudication based on previous research in this field [ 42].
In addition, that population of patients provides important methodological challenges for the adjudication of AMI based on the information obtained during routine clinical care, which might have further contributed to those findings.
For all cases of presumed SCA, three study physicians performed in-house adjudication of SCA cases based on the arrest circumstances, medical records and available autopsy data.
Additionally, a central pathology review committee (chaired by KWB) has been formed to document and review all the margin pathology of the surgical samples and the adjudication of the endpoint based on the pathology of the follow-up biopsy.
After unblinding and initial analyses, 12 patients were found to be misclassified as having gastric ulcers based on the adjudication of endoscopy reports, and analyses were re-run.
One borehole log is chosen based on the engineer adjudication and analysis is performed.
Fifty matched, caller-side transcripts were labeled as truthful or deceptive based on the subsequent adjudication of the cases.
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