In REDUCE-2, the primary end point analysis of upper gastrointestinal (GI) ulcers was 13.0% vs. 20.5% (P=0.0587) in the post-adjudication analysis.
In REDUCE-1, the primary end point analysis of gastric ulcers at 24 weeks with HZT-501 vs. ibuprofen was 12.7% vs. 22.9% (P=0.0044) in the post-adjudication analysis.
Assessment of the secondary ulcer end points in REDUCE-1 revealed that significantly fewer patients receiving HZT-501 developed upper GI ulcers in both the initial (NNT=9) and post-adjudication analysis (NNT=10), and significantly fewer patients developed duodenal ulcers (NNT=25).
Assessment of secondary end points in REDUCE-2 showed that the 6.7% reduction in life table estimate of gastric ulcers was not significant in the initial comparison (P=0.0795) and the 5.3% reduction in the post-adjudication analysis was not formally tested based on the predefined hierarchical testing sequence for the analysis.
One borehole log is chosen based on the engineer adjudication and analysis is performed.
But despite the promise of expansion Dr Hawkins acknowledged that Hawk-Eye's application in football is limited, and that the company would continue to develop its presence in other sports, both as a tool of adjudication and analysis.
We also discuss specific details of trial execution, in particular randomization, blinded outcome adjudication and analysis of the results, which are key to avoiding bias in the design and interpretation of such trials.
The smaller REDUCE-2 trial did not show a significant difference in the post-adjudication primary analysis of life table estimates of upper GI ulcers, with a P value of 0.0587; the secondary statistical comparison of crude proportions of upper GI ulcers revealed a P value of 0.0070.
CL: member of adjudication panel, data analysis, manuscript revising, final approval.
FF: blinded reader, member of adjudication panel, data analysis, manuscript revising, final approval.
HA: study concept, member of adjudication panel, data analysis, manuscript writing and revising, final approval.
