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Analysis of the incidence of cerebrovascular events based on adjudicated data showed no significant differences among treatment groups (Table 3).
The incidence of VTEs and cerebrovascular events, based on adjudicated data, was expressed as the rate in 1,000 women-years.
A total of 43 subjects (0.6%) reported VTEs based on adjudicated data (Table 5); the overall incidence of VTEs (deep vein thrombosis [DVT], pulmonary embolism [PE], or retinal vein thrombosis [RVT]) was generally higher among the active treatment groups compared with the placebo group.
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These differences may arise from disparate definitions of data quality but more likely relate to the reasons for adjudicating data quality, which differ according to the purview of these bodies.
To refine the analytical plan, we reviewed SIRS data as of November 2013 (without knowledge of the treatment allocation and recognising SIRS data is actively being adjudicated and data discrepancies reconciled).
The adjudicated event data included major adverse cardiac events (MACE), target lesion revascularisation (TLR), target vessel revascularisation (TVR), target vessel failure (TVF) and stent thrombosis.
Subsequently, research physicians independently adjudicate all data on potential events.
This database contains pharmacy claims data adjudicated from 49,000 US retail pharmacies, including available transaction data from >500,000 prescribers using 42,500 pharmacies.
Limitations include lack of formally adjudicated outcomes, information bias, and missing data.
In only two of the trials were the data adjudicated by blinded trial investigators.
If consensus between MF and VF could not be reached, the third party (JG) adjudicated how the data would be recorded.
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CEO of Professional Science Editing for Scientists @ prosciediting.com