Yet, it is interesting to note that the three genetically closest pairs of strains tend to segregate in the same or adjacent trait-based clusters (see arrows in Figure 7 and related clusters in Suppl. Figure 7 of Supplement S1).
This step returns an undirected graph U. Step 2. For each pair of non-adjacent traits y j and y j' with a common adjacent trait y j" in U (i.e., y j - y j" - y j'), search for a set S jj' containing y j" such that y j is independent of y j' conditional on S jj'.
If partial correlations of two non-adjacent traits (e.g., Y1 and Y3) that have a common adjacent trait (Y2) in such an undirected graph are dependent conditional on any possible set that includes the adjacent trait (Y2), the edges should be oriented towards the common adjacent trait (Y2), such as in Y1 → Y2 ← Y3.
Two adjacent trait-breed specific QTL on BTA3 at 112 and 113 Mb cumulatively explained 7.1% of additive genetic variance in ribeye muscle area in Shorthorn (Additional file 8).
Genetic correlations in same traits between adjacent levels of herd descriptors were close to 1, but declined for descriptor levels in greater distance.
However, during the early years of breeding and seed increase, there was some uncertainty among regulators about containment measures needed to prevent the movement of regulated GM traits into adjacent fields of conventional cotton and possibly into the human or animal food chain.
Similarly gene expression traits in adjacent normal tissue associated with DFS (Cox p < 0.01, Additional File 6, 7, 8 and 9, Table S3) were enriched for genes identified as differentially connected in the tumor tissue (p < 5.2e-69, fold 2.52).
Long (intergenic) non-coding RNAs have been shown to affect the expression of their neighbouring genes [ 30], thus suggesting the importance of positional conservation in properly regulating adjacent genes encoding various traits.
Eigengenes that are adjacent to a clinical trait may correspond to pathways (modules) that are associated with the clinical trait.
Likewise, BARC1.01Gm01_52253980 and adjacent markers have pan-trait, pan-population significance (Table 3 and Figure S1).
Given the close physical proximity of these SNPs, we initially considered the possibility that LD was driving the associations, leading to a high PVE for all the SNPs adjacent to the quantitative trait nucleotide.
