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First, selecting only the maximally significant locus without consideration for adjacent significance in either the 5 or 3' direction may produce artificially small peak boundaries.
We use the stream fields to reveal the changes in cluster assignments and in level of significance between two adjacent significance clusterings.
To reduce the number of hypothesis to be tested in the adjacent significance tests, genes were filtered based on the following criteria: all genes that were expressed under the estimated background intensity of 2 fluorescent units on at least 4 of the 10 arrays and genes with an interquantile range of less than 0.001 were excluded.
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Once selected the size of the sliding window and the shift between adjacent windows, the significance of regional enrichment in SF observed in each window, is calculated.
After thresholding the F map at each voxel (at P < 0.05), adjacent voxels in the significance mask were counted as a single cluster using the blob coloring algorithm based on six-neighbor connectedness.
These novel ncRNAs did not show any statistically significant enrichment in particular genomic positions such as regions with clustered ncRNAs, strand switch regions (regions where the coding strand changes) or regions adjacent to coding sequences (significance was defined as p-value < 0.05 in a genomic position permutation test), indicating a relatively uniform distribution on the genome.
The importance of children's decision-making competence is not confined to the medical context alone but may be of significance to adjacent fields, for instance children's competence to proceed to criminal adjudication or to be consulted in civil procedures, which requires further research.
Because many adjacent markers showed co-significance due to high LD (r between markers > 0.99), information redundancy exists for these markers.
Thus, present study can be used as a basis for evaluation of other repeats to unveil their combined significance within and adjacent to the coding regions.
Human DEC1 is highly expressed in various tumor types but not in the adjacent normal tissues, demonstrating the significance of this protein as an oncogenic marker.
For those DNA regions not pursued beyond the pilot phase, which were examined in only 37 pairs of cancer and adjacent tissue, we used a significance level of p ≤ 0.01.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com